Huijia Group tau tsim nyob rau xyoo 2007, tau tsav los ntawm cov khoom siv hluavtaws, tsom mus rau cov kev xav tau tseem ceeb ntawm cov neeg siv, nrog rau cov khoom zoo, tus nqi qis, thiab kev yooj yim, los tsim cov khoom siv thiab kev ua haujlwm. Raws li kev nkag siab zoo thiab kev tshawb fawb ntawm cov txheej txheem physiological ntawm cov kab mob nyob, Huijia integrates lub tswv yim ntawm ntsuab thev naus laus zis rau hauv biotechnology tshiab thiab cov txheej txheem tsim tawm tshiab. Kev saib xyuas ntau dua, ua ib lub koom haum ntawm Huijia Group, pab txhim kho cov khoom los ntawm cov txheej txheem fermentation. Raws li lub teb chaws high-tech enterprise, Vegamax tau tsim 6 lub hauv paus tsim khoom thiab muaj ntau xyoo dhau los ntawm kev tsim cov khoom xyaw zaub mov thiab cov khoom noj tsiaj. Raws li tus thawj coj hauv kev lag luam microbial fermentation, peb muaj 20 xyoo ntawm fermentation kev paub thiab zoo txhim kho bioavailability.
Vim li cas thiaj xaiv US
Peb lub Hoobkas
Huijia Group tau tsim nyob rau xyoo 2007, tau tsav los ntawm cov khoom siv hluavtaws, tsom mus rau cov kev xav tau tseem ceeb ntawm cov neeg siv, nrog rau cov khoom zoo, tus nqi qis, thiab kev yooj yim, los tsim cov khoom siv thiab kev ua haujlwm.
Peb Cov Khoom
Care More muaj cov khoom lag luam nplua nuj, thiab nws cov khoom lag luam thiab cov kev pabcuam muab cov kws kho tsiaj, cov neeg ua liaj ua teb thiab cov tswv tsiaj, zaub mov & tshuaj pleev ib ce kev lag luam nrog cov khoom siv dav dav thiab cov kev pabcuam kev paub los pab lawv daws nrog ntau yam teebmeem uas yuav tshwm sim thaum lub sijhawm ua haujlwm, ua teeb meem kev noj qab haus huv yooj yim dua nrog. Cov khoom lag luam feem ntau suav nrog tsiaj, tsiaj, khoom noj, tshuaj pleev ib ce, nroj tsuag.
Professional R & D pab neeg
Lub koom haum Green Technology Research Institute yog tus thawj coj los ntawm Dr. Yang Caimei, tus xibfwb / tus kws saib xyuas kev noj qab haus huv ntawm Zhejiang Agriculture thiab Forestry University thiab tus kws tshaj lij hauv xeev Zhejiang. Tam sim no, pab pawg tshawb fawb thiab kev tsim kho muaj ntau tshaj 50 tus tswv thiab tus kws kho mob qib R & D cov txuj ci los ntawm Zhejiang University, Tsinghua University, thiab Max Planck Institute hauv Tebchaws Yelemees, suav nrog 8 PhDs, 32 cov tub ntxhais kawm tiav, 5 tus kws tshaj lij hauv tebchaws, thiab 2 tus kws pab tswv yim thoob ntiaj teb.
Peb Qhov Kev Pabcuam
Kev saib xyuas ntau dua, sawv ntawm lub xub pwg ntawm cov neeg loj, nqis peev 20 xyoo kev tsim kho tshiab hauv microbiology thiab cov khoom tshwj xeeb los muab cov kev daws teeb meem ntsuab rau cov tsiaj txhu thiab cov tsiaj sib koom, tib neeg thiab cov nroj tsuag, los ntawm kev mob siab rau & kev paub txog hauv kev lag luam, thaum kawg xa cov txiaj ntsig zoo tshaj plaws rau cov neeg siv khoom.
LysoPro yog fermented hloov lysozyme nrog kev txhim kho cov kab mob thiab tshuaj tua kab mob ntau dua li qe dawb lysozyme thiab nkag mus rau hauv cov hlab ntsha.
SmartPond yog kev sib xyaw ntawm 4 probiotics rau bio-remediation. Probiotic tshwj xeeb tshaj yog cov kab mob anaerobic tuaj yeem tsis tsuas yog txo cov xim dub thiab tsw ntxhiab hauv qab tab sis kuj tswj cov dej zoo yam tsis muaj oxygen noj hauv pas dej.
P-Care yog ib qho postbiotic (swine poultry antibacterial peptide) muab tau los ntawm fermentation ntawm probiotics, ua ib qho tshuaj tua kab mob tsis muaj tshuaj tiv thaiv kab mob Gram-negative xws li Salmonella thiab E.coli. Tam sim no, kev tshawb fawb dav tau ua tiav ntawm cov metabolites nquag ntawm probiotics, suav nrog exopolysaccharides, bacteriocins, organic acids, luv-chain fatty acids, thiab vitamins. Cov dynamic metabolites no tau pom cov khoom zoo kawg li ntawm lawv cov tshuaj tiv thaiv kab mob, tiv thaiv qog, tshuaj tiv thaiv kab mob antioxidant thaum tseem nthuav tawm lub cev tiv thaiv kab mob thiab muaj peev xwm tiv thaiv lossis kho ntau yam kab mob metabolic.
VibPro yog aqua antibacterial peptide muab tau los ntawm probiotic fermentation, muab cov tshuaj tua kab mob tsis muaj tshuaj tua kab mob los ntawm vibrio xws li AHPND / EMS / TPD thiab lwm yam. nyob rau hauv kab mob kab mob nyob rau hauv no sector. Vibrio hom suav nrog V. anguillarum, V. harveyi, V. parahaemolyticus, thiab V. alginolyticus ua rau muaj kev hem thawj rau tsiaj noj qab haus huv thiab ua rau poob nyiaj txiag ntau.
P-Care yog ib qho postbiotic tau los ntawm kev fermentation ntawm probiotics, ua ib qho tshuaj tua kab mob tsis muaj tshuaj tiv thaiv kab mob Gram-negative xws li Salmonella thiab E.coli. Tam sim no, kev tshawb fawb dav tau ua tiav ntawm cov metabolites nquag ntawm probiotics, suav nrog exopolysaccharides, bacteriocins, organic acids, luv-chain fatty acids, thiab vitamins. Cov dynamic metabolites no tau pom cov khoom zoo kawg li ntawm lawv cov tshuaj tiv thaiv kab mob, tiv thaiv qog, tshuaj tiv thaiv kab mob antioxidant thaum tseem nthuav tawm lub cev tiv thaiv kab mob thiab muaj peev xwm tiv thaiv lossis kho ntau yam kab mob metabolic.
GutUp yog kev sib xyaw ua ke ntawm bacillus coagulans thiab clostridium butyricum uas ruaj khov thiab tsim cov kab mob acid.
Antimicrobial peptides yog luv-chain amino acid sequences tsim los ntawm tag nrho cov kab mob nyob rau hauv nws tus kheej tiv thaiv. Antimicrobial peptides muaj ib tug dav spectrum ntawm antibacterial, antifungal, antiparasitic, thiab antiviral zog. Kev tshawb fawb tsis ntev los no tau tsom mus rau kev qhia txog cov tshuaj tiv thaiv kab mob peptides rau hauv cov khoom siv polymer nrog rau kev siv tshuaj, ntim khoom noj, kev saib xyuas tus kheej, thiab tsev muag tshuaj. Antimicrobial peptides hauv AP cov ntaub ntawv zoo li yog ib lub tswv yim zoo rau kev txo qis cov zaub mov tsis zoo, txhim kho zaub mov ruaj ntseg, thiab tswj kom zoo.
Qhov zoo ntawm Liquid Antimicrobial Peptide
Nws tuaj yeem koom nrog hauv kev kho cov kab mob hauv cov hnyuv los tiv thaiv cov kab mob nkag mus rau hauv cov ntshav thiab txo cov kev hloov pauv, tswj cov synthesis ntawm txoj hnyuv epithelial nruj kev sib txuas, yog li txhawb txoj hnyuv maturation thiab kho kev ntxhov siab. Ntau thiab ntau cov kev tshawb fawb tau pom tias probiotics metabolites ua lub luag haujlwm hauv kev loj hlob ntawm plab hnyuv thaum ntxov ntawm cov tsiaj, kev tiv thaiv kab mob sib txawv, epithelial cell proliferation thiab lwm yam hnyuv loj hlob thiab kev loj hlob.
Qhov kev ua tau zoo ntawm qhov kev kho mob no txuas mus rau G- thiab G + cov kab mob, tshwj xeeb tshaj yog tsom rau salmonella thiab E.coli, vim nws cuam tshuam kev ncaj ncees ntawm lawv cov cell membranes. Los ntawm inducing tsim ntawm transmembrane ion channels, daim nyias nyias yog compromised, ua rau cellular to thiab thaum kawg ua rau cell tuag.
Probiotic metabolites siv cov tshuaj tua kab mob los ntawm ntau lub tswv yim ntawm kev ua, suav nrog cuam tshuam kev ncaj ncees ntawm cov ntaub so ntswg ntawm tes, cuam tshuam nrog nucleic acid ua haujlwm, cuam tshuam rau cov protein synthesis, thiab tswj cov kev ua haujlwm enzyme. Cov yam ntxwv no ua rau nws tsis zoo li yuav ua rau cov tshuaj tiv thaiv thiab cov kev mob tshwm sim, thiab tso cai rau kev siv tshuaj kho mob mus sij hawm ntev thiab kev tiv thaiv thaum ua liaj ua teb.
Probiotics tuaj yeem tsim ntau yam khoom siv metabolites, xws li luv- saw fatty acids, hydrogen peroxide, conjugated linoleic acid, low-fructose oligosaccharides, thiab bacteriocins, kom siv lawv cov teebmeem probiotic. Cov khoom no tau raug kuaj xyuas los ntawm kev kuaj thib peb thiab tsis muaj cov tshuaj tua kab mob, ua rau lawv ntsuab thiab nyab xeeb. Tshwj xeeb tshaj yog nyob rau hauv cov cheeb tsam uas txwv tsis pub tshuaj tua kab mob, lawv tuaj yeem hloov cov tshuaj tua kab mob kom siv cov tshuaj tua kab mob.
Antimicrobial peptides yog ib qho tshwj xeeb thiab ntau haiv neeg ntawm cov molecules, uas tau muab faib ua pawg sub raws li lawv cov amino acid muaj pes tsawg leeg thiab cov qauv. Antimicrobial peptides feem ntau yog nyob nruab nrab ntawm 12 thiab 50 amino acids.
These peptides include two or more positively charged residues provided by arginine, lysine or, in acidic environments, histidine, and a large proportion (generally >50%) ntawm hydrophobic residues.Cov txheej txheem thib ob ntawm cov molecules ua raws li 4 lub ntsiab lus, suav nrog i) -helical, ii) -stranded vim muaj 2 lossis ntau dua disulfide bonds, iii) -hairpin lossis voj vim muaj qhov ib qho nyiaj disulfide thiab / lossis cyclization ntawm peptide saw, thiab iv) txuas ntxiv.
Ntau ntawm cov peptides no yog unstructured nyob rau hauv cov tshuaj dawb, thiab quav rau hauv lawv qhov kawg configuration thaum muab faib mus rau hauv cov kab mob lom. Cov peptides muaj hydrophilic amino acid residues raws li ib sab thiab hydrophobic amino acid residues dlhos raws tus opposite sab ntawm ib tug helical molecule.Qhov amphipathicity ntawm antimicrobial peptides tso cai rau lawv faib mus rau hauv daim nyias nyias lipid bilayer. Lub peev xwm los koom nrog daim nyias nyias yog qhov tseem ceeb ntawm cov tshuaj tiv thaiv kab mob peptides, txawm hais tias daim nyias nyias permeabilization tsis tsim nyog. Cov peptides no muaj ntau yam tshuaj tiv thaiv kab mob xws li membrane permeabilization mus rau kev ua ntawm ntau lub hom phiaj cytoplasmic.
Ntxiv cov tshuaj tua kab mob thiab tam sim no muaj ntau yam khoom muaj nyob rau hauv khw muag tsiaj uas siv cov tshuaj tiv thaiv kab mob peptides (AMP's), los ntawm kev sib ntxiv ntawm cov khoom siv hluavtaws AMP los yog los ntawm kev suav nrog cov tshuaj paub los txhawb kev tsim cov khoom tsim tawm.
AMP's yog me me, cationic polypeptides uas ua lub luag haujlwm tseem ceeb hauv lub cev tsis muaj zog. Lawv muaj kev ua haujlwm dav dav tiv thaiv kab mob, kab mob thiab cov fungi, thiab hloov kho cov lus teb hauv zos los ntawm kev txhawb nqa ntawm leucocyte chemotaxis. Lawv yog secreted los ntawm epithelial thiab lub cev tiv thaiv kab mob, nrog upregulation tshwm sim nyob rau hauv lub ntsej muag ntawm tus kab mob los yog raug mob. Ob tsev neeg loj hauv cov tsiaj nyeg yog defensins thiab cathelicidins, uas muaj cov khoom zoo sib xws ntawm lub cev thiab kev ua haujlwm.
Nyob rau hauv lub ntsej muag ntawm kev cuam tshuam los ntawm cov kab mob, AMP's tau koom nrog ntau yam txheej txheem xws li kev nrhiav neeg ua haujlwm ntawm lwm lub cev tiv thaiv kab mob thiab los ntawm kev cuam tshuam ncaj qha rau cov kab mob / fungi. Defensins tuaj yeem txuas ncaj qha rau ntawm phab ntsa ntawm tes ntawm cov kab mob no thiab vim yog qhov zoo, lawv raug rub mus rau hauv cov cell membrane tsis zoo thiab ua ke los tsim cov pore, thaum kawg ua rau cellular cuam tshuam thiab tuag.
Lub peev xwm tseem ceeb ntawm daim tawv nqaij defensins tau hais txog hauv kev tshawb fawb ntawm ntau yam kab mob ntawm daim tawv nqaij, piv txwv li kev sib piv ntawm cov tawv nqaij lesional los ntawm tib neeg nrog atopic dermatitis (AD) rau cov tawv nqaij ntawm tib neeg nrog psoriasis. Cov pab pawg yav dhau los ua kom pom qhov qhia tau qis dua defensin thiab muaj ntau dua rau cov kab mob ntawm daim tawv nqaij, txawm tias ob qho tib si cuam tshuam nrog cov tawv nqaij tsis zoo. Yog li nws tau pom zoo tias qhov txo qis ntawm AMP's lossis kev tsim cov AMP tsis ua haujlwm tuaj yeem ua rau muaj kev cuam tshuam ntau dua rau daim tawv nqaij kab mob hauv AD. Txawm li cas los xij, qhov sib txawv ntawm qhov no, lwm cov kev tshawb fawb tau sau tseg tias muaj kev nce ntxiv hauv kev qhia ntawm qee qhov AMP hauv tib neeg thiab canine AD cov neeg mob.
Siv cov kev paub no rau kev siv tshuaj kho mob yog thaj tsam ntawm kev txaus siab ntxiv; Qee cov nroj tsuag rho tawm cuam tshuam rau qib ntawm AMP's thiab kev tshawb fawb tsis ntev los no hauv cov dev atopic tau pom tias txo qis hauv Staphylococcus spp. tom qab 14 hnub ntawm kev kho mob txhua hnub nrog cov tshuaj tsuag dej uas muaj 0.1% Peumus boldus nplooj thiab Spiraea ulmaria, piv rau pawg tswj hwm uas nyuam qhuav tau txais dej raws li cov tshuaj tsuag4.
Los ntawm cov kev tshawb fawb, nws tau pom tseeb tias AMP yog ib qho tseem ceeb ntawm lub cev tiv thaiv kab mob hauv lub cev los tiv thaiv cov kab mob sab nraud thiab tau lees paub kev tshawb nrhiav ntxiv txog lawv lub luag haujlwm hauv kev hloov kho cov kab mob ntawm daim tawv nqaij thiab yuav ua li cas lawv tuaj yeem siv ntxiv los ua cov tshuaj kho mob.
Mechanisms of Action of Liquid Antimicrobial Peptide
Antimicrobial peptides feem ntau muaj cov txiaj ntsig zoo, tso cai rau lawv cuam tshuam nrog cov kab mob tsis zoo uas cuam tshuam rau cov kab mob thiab cov qog nqaij hlav cancer, xws li phospholipid phosphatidylserine, O-glycosylated mucins, sialylated gangliosides, thiab heparin sulfates. Cov txheej txheem ntawm kev txiav txim ntawm cov peptides no sib txawv tab sis tuaj yeem yooj yim rau hauv ob pawg: membranolytic thiab non-membranolytic antimicrobial peptides.Qhov cuam tshuam ntawm daim nyias nyias los ntawm membranolytic antimicrobial peptides tuaj yeem piav qhia los ntawm plaub qauv:
Qauv Zauv:Tus qauv chim-stave qhia tias AMPs cuam tshuam nrog cov lipid bilayer ntawm microbial cell membrane los ua cov channel transmembrane lossis "barrel staves". Cov channel no tau xav tias cuam tshuam rau daim nyias nyias txoj kev ncaj ncees, ua rau kev tuag ntawm microbe.
Cov ntaub pua plag qauv:Cov ntaub pua plag qauv qhia tias AMPs adsorb mus rau lipid bilayer ntawm microbial cell membrane, tsim ib txheej tuab uas ua rau cov membrane ua permeabilized. Cov qauv no qhia tias AMP ua raws li "cov ntaub pua plag" uas npog lub ntsej muag ntawm tes, tiv thaiv cov microbe los ntawm kev ua haujlwm zoo.
Toroidal qauv:Tus qauv toroidal qhia tias AMPs cuam tshuam nrog cov lipid bilayer ntawm microbial cell membrane los tsim cov qauv toroidal, uas xav tias yuav hle tawm cov seem ntawm daim nyias nyias thiab ua rau tsim cov vesicles. Cov txheej txheem no yog xav tias cuam tshuam rau daim nyias nyias lub siab thiab ua rau cov microbe tuag.
Cov qauv tsis zoo toroidal-pore:Raws li cov qauv no, cov teeb meem AMPs qhwv ib ncig ntawm cov lipid bilayer thiab tsim ib lub pore, uas cuam tshuam rau daim nyias nyias txoj kev ncaj ncees thiab ua rau kev tuag ntawm microbe. Tsis zoo li tus qauv toroidal, uas qhia tias AMP tsim cov qauv toroidal ruaj khov, tus qauv toroidal-pore tsis zoo qhia tias AMP hloov tau thiab tsis tsim cov qauv toroidal ruaj khov. Lub peptide-lipid pore complex ua intrinsically disordered, nrog rau kev taw qhia ntawm peptide tsis zoo txhais.
Ntau txoj hauv kev tau siv los txiav txim siab cov txheej txheem ntawm kev ua haujlwm ntawm cov tshuaj tiv thaiv kab mob peptide. Tshwj xeeb, cov kev tshawb fawb NMR solid-state tau muab kev daws teeb meem atomic-theem piav qhia txog kev cuam tshuam ntawm daim nyias nyias los ntawm cov tshuaj tiv thaiv kab mob peptides. Nyob rau hauv xyoo tas los no, X-ray crystallography tau siv los piav qhia hauv atomic nthuav dav yuav ua li cas tsev neeg ntawm cov nroj tsuag defensins rupture membranes los ntawm kev txheeb xyuas cov phospholipids tseem ceeb hauv cov cell membranes ntawm cov kab mob. Tib neeg defensins tau xav tias yuav ua los ntawm cov txheej txheem zoo sib xws, tsom rau cov cell membrane lipids ua ib feem ntawm lawv txoj haujlwm.
Cov cationic antimicrobial peptides yog ib qho tseem ceeb ntawm kev tiv thaiv innate ntawm txhua hom ntawm lub neej. Xws li peptides tuaj yeem raug nthuav tawm los yog ntxias los ntawm cov kab mob lossis lawv cov khoom. Cov peptides zoo tshaj plaws muaj cov dej num zoo sib piv nrog ntau hom kab mob, nrog rau cov tshuaj tua kab mob tiv thaiv kab mob. Lawv tua sai heev, tsis yooj yim xaiv cov mutants resistant, yog synergistic nrog cov pa tshuaj tua kab mob, lwm yam peptides, thiab lysozyme, thiab muaj peev xwm tua kab mob nyob rau hauv cov tsiaj qauv. Nws paub tias kev kis kab mob, tshwj xeeb tshaj yog thaum kho nrog tshuaj tua kab mob, tuaj yeem ua rau tso tawm cov khoom siv kab mob xws li lipopolysaccharide (LPS) thiab lipoteichoic acid, uas ua rau muaj peev xwm ua rau tuag taus.
Hauv kev sib piv rau cov tshuaj tua kab mob, cov peptides yeej tiv thaiv cytokine induction los ntawm cov khoom siv kab mob hauv cov ntaub so ntswg kab lis kev cai thiab tib neeg cov ntshav, thiab lawv thaiv qhov pib ntawm sepsis hauv nas qauv ntawm endotoxemia. Raws li qhov no, qhov kev sim ntawm cov noob caj noob ces siv cov kab macrophage ntawm tes qhia tau tias tus qauv peptide, CEMA, thaiv qhov kev qhia ntawm ntau cov noob uas nws cov ntawv sau tau raug ntxias los ntawm LPS. Cov peptides ua qhov no nyob rau hauv ib feem los ntawm kev thaiv LPS kev cuam tshuam nrog cov ntshav protein LBP. Tsis tas li ntawd, CEMA nws tus kheej muaj kev cuam tshuam ncaj qha rau ntawm macrophage noob qhia. Vim hais tias cationic antimicrobial peptides raug ntxias los ntawm LPS thiab muaj peev xwm ua kom cov kab mob septic teb ntawm cov tsiaj hlwb rau LPS, peb xav tias, ntxiv rau lawv lub luag haujlwm hauv kev tua cov kab mob ncaj qha thiab lysozyme, lawv muaj lub luag haujlwm hauv kev tawm tswv yim tswj cytokine. teb. Tam sim no peb tab tom tsim cov peptides sib txawv raws li kev kho mob tiv thaiv kab mob tiv thaiv kab mob.
Cov tshuaj tua kab mob yog siv dav rau kev tiv thaiv kab mob thiab kev loj hlob ntawm kev loj hlob ntawm cov tsiaj nyeg thiab nqaij qaib ntau lawm. Nrog rau kev ua tiav ntawm cov tshuaj tua kab mob rau kev kho cov kab mob, qhov tshwm sim thiab kev nthuav tawm sai ntawm cov kab mob tshuaj tua kab mob ua rau muaj kev pheej hmoo loj rau tsiaj thiab tib neeg kev noj qab haus huv. Tam sim no, tshuaj tiv thaiv kab mob tau dhau los ua teeb meem loj zuj zus. Cov neeg tuag thoob ntiaj teb tau kwv yees tias yuav ncav cuag 10 lab los ntawm 2050 vim yog cov tshuaj tua kab mob tiv thaiv kab mob, uas ntau dua li cov neeg tuag tam sim no cuam tshuam nrog ntau hom mob qog noj ntshav. Vim li no, nws yog qhov yuav tsum tau ua sai sai los tsim cov tshuaj tua kab mob tshiab, xws li cov tshuaj hloov pauv raws li tshuaj tiv thaiv kab mob peptides (AMPs).
AMPs yog tsim los ntawm ntau yam kab mob thiab muaj lub luag haujlwm rau kev tiv thaiv tus tswv ntawm cov kab mob, ua ib feem ntawm kev tiv thaiv hauv lub cev. AMPs feem ntau yog nyob nruab nrab ntawm 12 thiab 50 amino acids nrog rau dav dav ntawm cov tshuaj tua kab mob tiv thaiv kab mob, cov poov xab, fungi, thiab kab mob, nrog rau kev ua haujlwm cytotoxic ntawm cov qog nqaij hlav cancer, tiv thaiv kab mob, thiab kev ua haujlwm immunomodulatory. Txog tam sim no, raws li lawv cov qauv theem nrab, AMPs haum rau plaub chav kawm loj. Cell membrane permeabilization los ntawm AMPs tau xav tias yog thawj lub tswv yim ntawm kev tua cov kab mob microbes lossis cov qog nqaij hlav cancer.
Nyob rau hauv xyoo tas los no, kev tshawb fawb ntawm AMPs thiab lawv cov ntawv thov tau dhau los ua ib qho ntawm cov chaw kub hauv ntau qhov chaw, tshwj xeeb tshaj yog hauv kev ua liaj ua teb. AMPs raug suav tias yog ib qho kev cog lus zoo tshaj plaws rau cov tshuaj tua kab mob, thiab muaj peev xwm ua tau zoo rau kev siv cov khoom noj ntxiv hauv swine, nqaij qaib thiab txawm tias ntses ntau lawm. Qee cov kev tshawb fawb qhia AMPs li pub additives muaj txiaj ntsig zoo piv nrog cov tshuaj tua kab mob, suav nrog:
Broad-spectrum (antibacterial, antifungal, thiab antiviral) cuam tshuam
Tsawg theem ntawm induced kuj
Txhim kho kev loj hlob
Txhawb nqa cov zaub mov digestibility
Modulation ntawm plab microbiota
Txhim khu kev tiv thaiv kab mob
Tsis tas li ntawd, AMPs tsis tsuas yog sawv cev rau lwm cov tshuaj tua kab mob raws li cov tshuaj tiv thaiv kab mob kev loj hlob (AGP) tab sis kuj yog cov kws kho mob zoo heev rau kev tiv thaiv kab mob tsiaj, kev tswj hwm, thiab kev kho mob los ntawm kev ncaj qha ntxiv rau tsiaj pub raws li cov tshuaj tiv thaiv kab mob los tiv thaiv tsiaj.
Ua ib pab neeg nrog kev paub zoo tshaj plaws hauv kev tshawb fawb pub tsiaj thiab tsiaj noj zaub mov, Lifeasible muab cov kev pabcuam AMPs tawm tsam cov khoom noj ntxiv kom ua tau raws li kev tsim ua liaj ua teb rau kev noj qab haus huv ntsuab thiab kev nyab xeeb tsiaj pub additives, suav nrog:
AMPs synthesis service
AMPs kev kuaj xyuas kev ua haujlwm
Kev txhim kho AMPs
AMPs hloov kho thiab tsim
Nuclear magnetic resonance (NMR) tau ua lub luag haujlwm tseem ceeb hauv kev txiav txim siab cov ntsiab lus ntawm AMPs. Kev tsom xam ntawm peptide tus qauv peb-seem tau muab kev nkag siab tob rau hauv lawv txoj haujlwm. Ob-dimensional NMR txoj kev yog tsuas yog siv rau kev tau txais cov qauv peb-dimensional rau AMPs me me uas tuaj yeem muab faib ua tsib chav kawm raws li lawv cov qauv theem nrab. Txawm hais tias cov peptides no tseem tsis tau tsim nyob rau hauv cov kev daws teeb meem, lawv tuaj yeem siv cov yam ntxwv tshwj xeeb tom qab tuaj ntsib nrog daim nyias nyias. Plaub yam ntxwv zoo li no tau pom, uas yog alpha-helical, beta stranded, beta-hairpin los yog voj, thiab txuas ntxiv conformation. Cov qauv no tau lees paub los ntawm NMR, CD, lossis homology qauv kev tshawb fawb, qhov twg cov qauv atomic ntawm lub hom phiaj yog tsim los ntawm nws cov amino acids thiab cov qauv peb sab ntawm tus qauv. Feem ntau ntawm cov AMPs yog cov-helical conformations. Ib tug loj tus naj npawb ntawm sequences tau raug tshaj tawm nyob rau hauv cov chav kawm no, uas muaj xws li ob qho tib si ib txwm cais thiab chemically synthesized peptides. Hauv cov tshuaj aqueous, -helical AMPs muaj cov qauv linear, thiab thaum sib cuag nrog cov kab mob hauv cov kab mob los yog cov kuab tshuaj organic, nws tsim cov qauv amphipathic helical. Cov qauv amphipathic helical tso cai rau -helix AMPs rau burrow tob rau hauv phospholipid bilayer thiab cuam tshuam cov membrane kev ncaj ncees. Cov tshuaj tiv thaiv kab mob Myeloid peptide los ntawm cov tsiaj ua liaj ua teb sib txawv, xws li BMAP-27, SMAP-29, thiab PMAP{12}}, txhua tus muaj -helix ua lawv cov qauv thib ob.
Nyob rau hauv dav dav, -sheet AMPs yog cyclic molecules muaj li ntawm tsawg kawg yog ob antiparallel -sheets stabilized los ntawm intramolecular disulfide bonds. Cov-daim peptides tau txiav txim ntau dua hauv cov tshuaj aqueous vim lawv cov qauv nruj thiab tsis ua rau muaj kev hloov pauv loj xws li helical peptides raws li kev sib cuam tshuam ntawm daim nyias nyias. Tsis zoo li -helix, cov qauv siv tshuab tom qab -cov ntawv tshuaj tiv thaiv kab mob tsis nkag siab zoo. Cov-paj peptides muaj feem ntau cov nroj tsuag defensins, tsiaj txhu defensins thiab defensins (BNBDs, Bovine defensin-1, porcine -defensin), kab defensins, proline-nplua nuj antibacterial peptides, protegrin, thiab tachyplins. Defensins yog cov kev tshawb fawb zoo-daim ntawv peptides uas tsim nyob rau hauv neutrophils, macrophages, thiab epithelial hlwb raws li inactive precursors. Protegrin pawg ntawm AMPs los ntawm porcine muaj cov qauv zoo-elucidated. Cov tswv cuab ntawm pawg protegrin, PG-1 PG-2 PG-3, thiab PG-5 yog tsim los ntawm ob qho kev sib piv -cov ntawv sib txuas los ntawm kev tig.
Loop AMPs muaj cov qauv voj voog ruaj khov los ntawm amide, disulfide, thiab isopeptides bonds. Thanatin, ib tug tswv cuab tseem ceeb ntawm pab pawg no yog cais los ntawm cov kab mob spinning tub rog. Ib daim ntawv cog lus ntawm ib qho disulfide ntawm residue 11 thiab 18 stabilizes thiab muab thanatin nws tus yam ntxwv qauv.
Extended peptides tsis muaj cov qauv thib ob classical. Feem ntau, lawv muaj ntau cov amino acids, nrog rau cov seem ntawm glycine, arginine, tryptophan, proline, thiab histidine. Cov qauv yog ruaj khov los ntawm hydrogen daim ntawv cog lus thiab Vander Waal kev cuam tshuam nrog phospholipid bilayer. Indolicidin muaj qhov txuas ntxiv poly-L-proline II helix ua cov qauv thib ob; Txawm li cas los xij, nyob rau hauv ib puag ncig nruab nrab DPC, lub pob txha peptide siv lub nkoj zoo. Ob peb AMPs tsis koom nrog ib qho ntawm cov chav kawm no, thiab qee qhov tshwm sim hauv daim ntawv sau ua ke lossis thaum sib txuas lus nrog daim nyias nyias. Cov nroj tsuag-derived circulin A yog ib qho piv txwv meej ntawm qhov no, muaj xws li kev sib koom ua ke -helix thiab -sheet qauv uas ua rau lub voj voog cysteine pob.
FAQ
Cim npe nrov: p-care l, Tuam Tshoj p-care l manufacturers, lwm tus neeg, Hoobkas
